Applications of nitrogen monoxide for medical treatment

Using NO as a vasodilator:

Exogenous NO gas diffuses through the alveoli to the lung vascular smooth muscle cells and causes vasodilation.

When NO gas enters the bloodstream, it is rapidly inactivated by hemoglobin and vasodilator effect is concentrated in the pulmonary vasculature and does not show in systemic vasodilation.

Unlike other vasodilators such as Prostacyclin, Magnesium sulphate, … NO is an intravenous infusion that causes systemic vasodilation and a drop in blood pressure.

This selective vasodilator effect makes the use of NO gas in curing more effective and safer.

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Using nitrogen monoxide to treat respiratory failure in infants:

Currently, there are many research reports showing the effectiveness of breathing NO when treating severe respiratory failure for infants due to pulmonary hypertension.

Moreover, this method has lower cost and high applicability. Recent studies have shown that breathing NO can be used for a various treatment, evaluation and prevention of cardiovascular and respiratory diseases.

Persistent pulmonary hypertension in infants is a common cause of respiratory failure. Conventional treatment for pulmonary hypertension includes mechanical ventilation, sedation, and alkalosis of the blood.

A randomized controlled clinical trial showed that the NO breathing effect improved oxygen into the arterial blood safely, reducing the need for ECMO (Oxidation of blood through the outer membrane). At the same time, treatment costs and the risk of invasion are reduced, without any side effects.

Some profile about NO gas

In the following section, we will provide you more useful information about the close relationship between NO and the cells, the cardiovascular system or the entire human body and the nitrogen monoxide’s mechanism of action on organ systems as well as its applications to cure diseases.

What is nitrogen monoxide or NO gas?

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Nitrogen monoxide is a colorless, odorless gas with the chemical formula: NO. Nitric oxide, also known as nitrogen monoxide, is unstable in air and easily oxidized at room temperature to produce nitrogen dioxide gas.

NO gas is produced from enzymes in the body, which is responsible for dilating blood vessels, sending oxygen and nutrients to muscle cells and parts of the body, helping strengthen muscles, increasing endurance, and stabilizing energy metabolism.

The relationship between NO gas with humans – How is NO gas produced from the body?

In 1987, the two scientists Furchgott and Zawadzki demonstrated that the vasodilation under the action of acetylcholine requires the presence of endothelial cells.

Science magazine called NO as “Molecule of the Year” in 1992. Nowadays, it has been found that NO is an important molecule of human body.

The human respiratory tract creates NO in the nasal mucosa with concentrations from 25 to 64 ppb. This concentration will decrease significantly when going deeper into the respiratory tract, there will be only 1-6 ppb of NO gas in the mouth, trachea, and bronchi.

At a low concentration, NO gas helps cells survive and grow. However, when at high concentrations, NO gas causes growth cessation, death and aging of cell.

Effects of NO gas on sexual function

For men, erectile dysfunction is due to the lack of NO, the hindrance to cycle of generating guanosine monophosphate (abbreviated GMP) or due to psychological factors, medical conditions, the use of certain drugs or age.

Erectile dysfunction is a common medical condition, negatively affecting the patient’s life and happiness in their family.

The top drugs used in emergency ischemic heart disease are mostly nitrogen-based. When the coronary artery lumen of the heart is atherosclerosis or narrowed, it can easily lead to insufficient blood feeding to an area of ​​the heart muscle, threatening myocardial infarction or angina, Nitroglycerin is the top first aid drug that quickly dilates blood vessels to feed blood to the heart.

In recent years, many kinds of drug that inhibit the enzyme (enzyme) phosphodiesterase 5 are used for the treatment of erectile dysfunction. It is a specific enzyme of the cavernous body (PDE5).

Ảnh hưởng của NO trong chức năng tình dục

Với nam giới việc rối loạn chức năng gây cương dương vật là do thiếu NO, hay do chu trình tạo ra guanosine monophosphat (viết tắt GMP) bị cản trở. Hoặc do các yếu tố tâm lý, các bệnh lý, do sử dụng một số loại thuốc hoặc tuổi tác.

Rối loạn cương dương là một bệnh lý phổ biến, gây ảnh hưởng tiêu cực tới chất lượng cuộc sống và hạnh phúc gia đình của người bệnh.

Những năm gần đây việc điều trị rối loạn cương dương được sử dụng nhiều loại thuốc ức chế được men (enzym) phosphodiesterase 5. Nó là 1 loại enzym đặc hiệu của thể hang dương vật (được viết tắt PDE5).

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