In the following section, we will provide you more useful information about the close relationship between NO and the cells, the cardiovascular system or the entire human body and the nitrogen monoxide’s mechanism of action on organ systems as well as its applications to cure diseases.
What is nitrogen monoxide or NO gas?
Nitrogen monoxide is a colorless, odorless gas with the chemical formula: NO. Nitric oxide, also known as nitrogen monoxide, is unstable in air and easily oxidized at room temperature to produce nitrogen dioxide gas.
NO gas is produced from enzymes in the body, which is responsible for dilating blood vessels, sending oxygen and nutrients to muscle cells and parts of the body, helping strengthen muscles, increasing endurance, and stabilizing energy metabolism.
The relationship between NO gas with humans – How is NO gas produced from the body?
In 1987, the two scientists Furchgott and Zawadzki demonstrated that the vasodilation under the action of acetylcholine requires the presence of endothelial cells.
Science magazine called NO as “Molecule of the Year” in 1992. Nowadays, it has been found that NO is an important molecule of human body.
The human respiratory tract creates NO in the nasal mucosa with concentrations from 25 to 64 ppb. This concentration will decrease significantly when going deeper into the respiratory tract, there will be only 1-6 ppb of NO gas in the mouth, trachea, and bronchi.
At a low concentration, NO gas helps cells survive and grow. However, when at high concentrations, NO gas causes growth cessation, death and aging of cell.
Effects of NO gas on sexual function
For men, erectile dysfunction is due to the lack of NO, the hindrance to cycle of generating guanosine monophosphate (abbreviated GMP) or due to psychological factors, medical conditions, the use of certain drugs or age.
Erectile dysfunction is a common medical condition, negatively affecting the patient’s life and happiness in their family.
The top drugs used in emergency ischemic heart disease are mostly nitrogen-based. When the coronary artery lumen of the heart is atherosclerosis or narrowed, it can easily lead to insufficient blood feeding to an area of the heart muscle, threatening myocardial infarction or angina, Nitroglycerin is the top first aid drug that quickly dilates blood vessels to feed blood to the heart.
In recent years, many kinds of drug that inhibit the enzyme (enzyme) phosphodiesterase 5 are used for the treatment of erectile dysfunction. It is a specific enzyme of the cavernous body (PDE5).